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Open AccessShort Note

(2R,4aS,6aS,12bR,14aS,14bR)10-Hydroxy-N-(4-((6-methoxyquinolin-8-yl)amino)pentyl)-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxamide

by

Yuhan Xie

,

Houin Kuan

,

Qin Wei

,

Alessandra Gianoncelli

,

Giovanni Ribaudo

and

Paolo Coghi

Molbank 2023, 2023(3), M1716; https://doi.org/10.3390/M1716 - 29 Aug 2023

Viewed by 172

Abstract

We herein report the synthesis of a derivative of the natural compound celastrol linked to the antimalarial drug primaquine through an amide obtained by the activation of the carboxylic acid with HOBt/EDC. The chemical structure of the new molecule was fully characterized by [...] Read more.

We herein report the synthesis of a derivative of the natural compound celastrol linked to the antimalarial drug primaquine through an amide obtained by the activation of the carboxylic acid with HOBt/EDC. The chemical structure of the new molecule was fully characterized by proton nuclear magnetic resonance (¹H-NMR), carbon-13 nuclear magnetic resonance (¹³C-NMR), heteronuclear single quantum coherence (HSQC), correlation spectroscopy (¹H-¹H-COSY), distortionless enhancement by polarization transfer (DEPT), mass spectrometry, Fourier-transform infrared (FTIR), and ultraviolet (UV) spectroscopies. Computational studies were enrolled to predict the interaction of the synthesized compound with sarco-endoplasmic reticulum (SR) Ca²⁺ transport ATPase (SERCA), a target of relevance for developing new therapeutics against arthritis. The drug-likeness of the compound was also investigated by predicting its pharmacokinetic properties. Full article

(This article belongs to the Section Organic Synthesis)

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Open AccessCommunication

Synthesis of a Novel 2-((4,5-Diphenyl-4H-1,2,4-triazol-3-yl)thio)acetaldehyde as a Bisulfite Adduct

by

Beniamin-Nicolae Pintea

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Ion Burcă

,

Valentin Badea

and

Francisc Peter

Molbank 2023, 2023(3), M1715; https://doi.org/10.3390/M1715 - 24 Aug 2023

Viewed by 208

Abstract

The scope of the current work was to synthesize an S-alkylated 1,2,4-triazole-3-thiol derivative. Synthesis was carried out in two steps: in the first step, 4,5-diphenyl-4H-1,2,4-triazole-3-thiol was S-alkylated using a halogenated acetal and cesium carbonate. In the second step, several [...] Read more.

The scope of the current work was to synthesize an S-alkylated 1,2,4-triazole-3-thiol derivative. Synthesis was carried out in two steps: in the first step, 4,5-diphenyl-4H-1,2,4-triazole-3-thiol was S-alkylated using a halogenated acetal and cesium carbonate. In the second step, several acetal deprotection procedures were tested, and the aldehyde obtained was isolated as a bisulfite adduct. The structures of the new compounds were characterized by FT-IR, 1D, and 2D NMR spectroscopic methods. Full article

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Open AccessShort Note

(E)-2-(6-(4′-(Diphenylamino)-[1,1′-biphenyl]-2-yl)-[1,2,5]oxadiazolo[3,4-b]pyrazin-5(4H)-ylidene)-2-(6-(4′-(diphenylamino)-[1,1′-biphenyl]-2-yl)-[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl)acetonitrile

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Molbank 2023, 2023(3), M1714; https://doi.org/10.3390/M1714 - 21 Aug 2023

Viewed by 289

Abstract

[1,2,5]Oxadiazolo[3,4-b]pyrazines are of great interest due to their promising photophysical and electrochemical properties, as well their potential use in a wide range of electronic devices. Herein, we report on the preparation of the unexpected product derived from the interaction of 2′-([1,2,5]oxadiazolo[3,4- [...] Read more.

[1,2,5]Oxadiazolo[3,4-b]pyrazines are of great interest due to their promising photophysical and electrochemical properties, as well their potential use in a wide range of electronic devices. Herein, we report on the preparation of the unexpected product derived from the interaction of 2′-([1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl)-N,N-diphenyl-[1,1′-biphenyl]-4-amine with 2-cyanoacetic acid under basic conditions. The resulting product was characterized using ¹H and ¹³C NMR spectra, high resolution mass spectrometry, Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction analyses. Furthermore, its photophysical and electrochemical properties were studied using cyclic voltammetry, UV–Vis, and emission spectroscopy. The experimental results have been further rationalized through theoretical DFT calculations. Full article

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Open AccessCommunication

Synthesis of a New α-Azidomethyl Styrene from Safrole via a Dearomative Rearrangement

by

Stephen R. Isbel

and

Alejandro Bugarin

Molbank 2023, 2023(3), M1713; https://doi.org/10.3390/M1713 - 16 Aug 2023

Viewed by 246

Abstract

There is a growing interest in developing more efficient synthetic alternatives for the synthesis of nitrogen-containing allylic compounds. This article presents a straightforward two-step protocol to produce 5-(3-azidoprop-1-en-2-yl)benzo[d][1,3]dioxole 4 from the natural product safrole. The method yielded the expected α-azidomethyl styrene [...] Read more.

There is a growing interest in developing more efficient synthetic alternatives for the synthesis of nitrogen-containing allylic compounds. This article presents a straightforward two-step protocol to produce 5-(3-azidoprop-1-en-2-yl)benzo[d][1,3]dioxole 4 from the natural product safrole. The method yielded the expected α-azidomethyl styrene 4, in good yield, via a dearomative rearrangement. Full article

(This article belongs to the Section Organic Synthesis)

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Open AccessCommunication

Friedländer-Type Reaction of 4-Cholesten-3-one with 2′-Aminoacetophenone: Angular versus Linear Quinoline-Fused Steroids

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Molbank 2023, 2023(3), M1712; https://doi.org/10.3390/M1712 - 16 Aug 2023

Viewed by 238

Abstract

To optimize the experimental conditions used for the Friedländer-type condensation, an angular fused 4-substituted quinoline steroid has been obtained in very high yield and regioselectivity using readily available 4-cholesten-3-one and 2′-aminoacetophenone. Moreover, by varying the reaction conditions and the catalyst, the corresponding linear [...] Read more.

To optimize the experimental conditions used for the Friedländer-type condensation, an angular fused 4-substituted quinoline steroid has been obtained in very high yield and regioselectivity using readily available 4-cholesten-3-one and 2′-aminoacetophenone. Moreover, by varying the reaction conditions and the catalyst, the corresponding linear regioisomer was also achieved with an acceptable isolated yield and high chemoselectivity. Both structures have been definitively elucidated via 2D-NMR and fully characterized. Full article

(This article belongs to the Section Organic Synthesis)

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Open AccessShort Note

Pentapotassium Bis(hydrogenphospate) Dihydrogenphospate Monohydrate

by

Camila Caro Garrido

,

Tom Leyssens

and

Koen Robeyns

Molbank 2023, 2023(3), M1711; https://doi.org/10.3390/M1711 - 14 Aug 2023

Viewed by 282

Abstract

The structure of K₅(HPO₄)₂(H₂PO₄)·H₂O was determined via single crystal diffraction. The crystal structures of phosphate salts of potassium have been known since the early days of crystallography. Here, we present a new monohydrate adduct between K₂HPO₄ and KH₂PO₄. Full article

(This article belongs to the Section Structure Determination)

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Open AccessShort Note

Tributyl(1-((dimethylamino)(dimethyliminio)methyl)-1,4-dihydropyridin-4-yl)phosphonium Ditrifluoromethanesulfonate

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Molbank 2023, 2023(3), M1710; https://doi.org/10.3390/M1710 - 09 Aug 2023

Viewed by 344

Abstract

Site-selective functionalization of pyridines is a crucial tool for the synthesis of diverse pharmaceuticals and materials. We introduced diiminium pyridine adducts as highly convenient and potent Lewis acids. We report that tributylphosphine selectively adds to the 4-position of pyridine in tetramethyldiiminium pyridine ditrifluoromethanesulfonate, [...] Read more.

Site-selective functionalization of pyridines is a crucial tool for the synthesis of diverse pharmaceuticals and materials. We introduced diiminium pyridine adducts as highly convenient and potent Lewis acids. We report that tributylphosphine selectively adds to the 4-position of pyridine in tetramethyldiiminium pyridine ditrifluoromethanesulfonate, resulting in the formation of the title compound. This finding represents an advancement towards the utilization of diiminium units as organic reagents or catalysts for pyridine functionalization. We also employ computational models to determine fluoride and hydride ion affinities, Fukui function f⁺(r), molecular electrostatic potential, and pKa values, providing valuable insights for future investigations in this area. Full article

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Open AccessShort Note

(E)-2-(1,3-Diphenylallyl)-3,5-dimethoxyphenol

by

Lara Mollà-Guerola

and

Alejandro Baeza

Molbank 2023, 2023(3), M1709; https://doi.org/10.3390/M1709 - 04 Aug 2023

Viewed by 343

Abstract

The synthesis of (E)-2-(1,3-diphenylallyl)-3,5-dimethoxyphenol is described by means of the reaction of 3,5-dimethoxyphenol with (E)-1,3-diphenylprop-2-en-1-ol in 1,1,1,3,3,3-hexafluoroispropanol (HFIP), which acts as a solvent and reaction promoter. The reaction proceeds smoothly to afford the mentioned compound in high yield under [...] Read more.

The synthesis of (E)-2-(1,3-diphenylallyl)-3,5-dimethoxyphenol is described by means of the reaction of 3,5-dimethoxyphenol with (E)-1,3-diphenylprop-2-en-1-ol in 1,1,1,3,3,3-hexafluoroispropanol (HFIP), which acts as a solvent and reaction promoter. The reaction proceeds smoothly to afford the mentioned compound in high yield under a metal and additive-free procedure. The corresponding allylated phenol has been fully characterized. Full article

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Open AccessShort Note

Isoamyl (E)-3-(3,4-Dimethoxyphenyl)acrylate

by

Egar Pamela

,

Lukman Atmaja

and

Mardi Santoso

Molbank 2023, 2023(3), M1708; https://doi.org/10.3390/M1708 - 02 Aug 2023

Viewed by 282

Abstract

Isoamyl (E)-3-(3,4-dimethoxyphenyl)acrylate (1) was obtained from the 2-methyl-6-nitrobenzoic anhydride (MNBA)/4-dimethylaminopyridine (DMAP)-catalyzed reaction at room temperature for 190 min in dichloromethane with a yield of 95%. The structure of isoamyl (E)-3-(3,4-dimethoxyphenyl)acrylate (1) was elucidated using NMR, [...] Read more.

Isoamyl (E)-3-(3,4-dimethoxyphenyl)acrylate (1) was obtained from the 2-methyl-6-nitrobenzoic anhydride (MNBA)/4-dimethylaminopyridine (DMAP)-catalyzed reaction at room temperature for 190 min in dichloromethane with a yield of 95%. The structure of isoamyl (E)-3-(3,4-dimethoxyphenyl)acrylate (1) was elucidated using NMR, FTIR, and high-resolution mass spectrometry. In vitro sun protection factor evaluation exhibited a value of 37.10 ± 0.03 which indicates that isoamyl (E)-3-(3,4-dimethoxyphenyl)acrylate (1) is a sunscreen agent with high protection. Full article

(This article belongs to the Section Organic Synthesis)

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Open AccessCommunication

Synthesis of Novel Diterpenic Peptides via the Ugi Reaction and Their Anticancer Activities

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Molbank 2023, 2023(3), M1707; https://doi.org/10.3390/M1707 - 01 Aug 2023

Viewed by 243

Abstract

Novel diterpenic peptide derivatives were synthesized via the Ugi four-component reaction at ambient temperature. The protocol employed a reaction between formaldehyde, benzyl amine, the corresponding diterpene acid, and ethyl 2-isocyanoacetate. The anticancer properties of the compounds were studied in vitro. Full article

(This article belongs to the Section Organic Synthesis)

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Open AccessShort Note

N′-(5-Bromofuran-2-carbonyl)isonicotinohydrazide

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Molbank 2023, 2023(3), M1706; https://doi.org/10.3390/M1706 - 01 Aug 2023

Viewed by 354

Abstract

N′-(5-bromofuran-2-carbonyl)isonicotinohydrazide (1) was obtained in the form of a colorless solid from the 2-methyl-6-nitrobenzoic anhydride (MNBA)/4-dimethylaminopyridine (DMAP)-catalyzed reaction of 5-bromofuran-2-carboxylic acid and isoniazid in dichloromethane at room temperature with a yield of 83%. The structure of N′-(5-bromofuran-2-carbonyl)isonicotinohydrazide (1 [...] Read more.

N′-(5-bromofuran-2-carbonyl)isonicotinohydrazide (1) was obtained in the form of a colorless solid from the 2-methyl-6-nitrobenzoic anhydride (MNBA)/4-dimethylaminopyridine (DMAP)-catalyzed reaction of 5-bromofuran-2-carboxylic acid and isoniazid in dichloromethane at room temperature with a yield of 83%. The structure of N′-(5-bromofuran-2-carbonyl)isonicotinohydrazide (1) was elucidated using ¹H NMR, ¹³C NMR, FTIR, and high-resolution mass spectrometry. Molecular docking screening of the title compound (1) on cyclooxygenase-2 (COX-2) protein (PDB ID: 5IKR) indicated that compound (1) has a good binding affinity, suggesting that further structure optimization and in-depth research can be carried out on compound (1) as a potential COX-2 inhibitor. Full article

(This article belongs to the Section Organic Synthesis)

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Open AccessShort Note

4-(4-ethoxyphenyl)-5-(4-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

by

Ion Burcă

,

Valentin Badea

,

Calin Deleanu

,

Vasile-Nicolae Bercean

and

Francisc Péter

Molbank 2023, 2023(3), M1705; https://doi.org/10.3390/M1705 - 01 Aug 2023

Viewed by 243

Abstract

A new triazol-3-one resulted unexpectedly from the reduction reaction of a heterocyclic thioketone using sodium borohydride in pyridine containing a small amount of water. The structure of the new compound was characterised using FT-IR, 1D and 2D NMR, and HRMS spectroscopic methods. Full article

(This article belongs to the Special Issue Molecules from Side Reactions II)

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Open AccessCommunication

N-(((1S,5R)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)-3-dodecan/tetradecanamido-N,N-dimethylpropan-1-aminium Bromide

by

Liliya E. Nikitina

,

Ilmir R. Gilfanov

,

Roman S. Pavelyev

,

Svetlana A. Lisovskaya

,

Elena Y. Trizna

,

Ilfat Z. Rakhmatullin

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Olga V. Ostolopovskaya

,

Larisa L. Frolova

and

Airat R. Kayumov

Molbank 2023, 2023(3), M1704; https://doi.org/10.3390/M1704 - 26 Jul 2023

Viewed by 272

Abstract

The syntheses of the title compounds were performed using lauric and myristic acids. The compounds obtained were characterized using ¹H-, ¹³C-NMR and 2D ¹H-¹H COSY, ¹H-¹³C HSQC NMR, IR, and high-resolution mass spectrometry. Both compounds [...] Read more.

The syntheses of the title compounds were performed using lauric and myristic acids. The compounds obtained were characterized using ¹H-, ¹³C-NMR and 2D ¹H-¹H COSY, ¹H-¹³C HSQC NMR, IR, and high-resolution mass spectrometry. Both compounds exhibited bactericidal activity on S. aureus comparable to that of a reference drug (miramistin). Compound 10, with lauric acid fragment, had a 16-fold higher activity on P. aeruginosa compared to compound 11, which in turn contains myristic acid fragment (with minimum inhibitory concentrations of 32 and 512 μg/mL, respectively). Compound 11 exhibited a pronounced activity against all types of fungi (higher than the activity of miramistin), while the activity of compound 10 was considerably lower. Thus, compound 11 can serve as a promising antimicrobial agent for the treatment of various fungal and staphylococcal infections, while compound 10 is of interest to treat P. aeruginosa-associated infections. Full article

(This article belongs to the Section Organic Synthesis)

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Open AccessShort Note

2,7-Bis(pyridin-4-ylethynyl)-9H-carbazole

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Molbank 2023, 2023(3), M1703; https://doi.org/10.3390/M1703 - 24 Jul 2023

Viewed by 288

Abstract

2,7-Bis(pyridin-4-ylethynyl)-9H-carbazole (1) was synthesized by reacting 4-ethynylpyridine hydrochloride with 2,7-dibromo-9H-carbazole. The full characterization of compound 1 is presented, and the crystal structure of its monohydrate was determined by single-crystal XRD analysis. Full article

(This article belongs to the Section Structure Determination)

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Open AccessShort Note

6,7-Dihydroxy-5,8-dimethoxy-2H-chromen-2-one

by

Olga I. Adaeva

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Dmitry V. Demchuk

and

Victor V. Semenov

Molbank 2023, 2023(3), M1702; https://doi.org/10.3390/M1702 - 23 Jul 2023

Viewed by 294

Abstract

This article presents a novel approach for synthesizing a new 5,8-dimethoxy derivative of esculetin via the selective cleavage of the methylene bridge in sabandin—naturally occurring and easily synthetically accessible methoxylated coumarin. A high selectivity is achieved by using acetoxylation of methylenedioxy group with [...] Read more.

This article presents a novel approach for synthesizing a new 5,8-dimethoxy derivative of esculetin via the selective cleavage of the methylene bridge in sabandin—naturally occurring and easily synthetically accessible methoxylated coumarin. A high selectivity is achieved by using acetoxylation of methylenedioxy group with lead tetraacetate. Natural coumarin sabandin as a starting compound was prepared in a few simple steps from 5-allyl-4,7-dimethoxybenzo[d][1,3]dioxole (apiol), which is readily available from parsley and dill seed extracts. The developed method enables an efficient and straightforward synthesis of a new derivative of esculetin with potential medicinal and therapeutic applications. Full article

(This article belongs to the Section Organic Synthesis)

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